Hematology topics for USMLE Step 1
Hematology topics for USMLE Step 1
Hematopoietic and Lymphoreticular Systems
Normal processes
- embryonic development, fetal maturation, and perinatal changes
- organ structure and function
- cell/tissue structure and function
- production and function of erythrocytes, hemoglobin, O2 and CO2 transport, transport proteins
- production and function of leukocytes and the lymphoreticular system
- production and function of platelets
- production and function of coagulation and fibrinolytic factors
- repair, regeneration, and changes associated with stage of life
Abnormal processes
- infectious, inflammatory, and immunologic disorders
- infections of the blood, reticuloendothelial system, and lymphatics
- allergic and anaphylactic reactions and other immunopathologic mechanisms
- acquired disorders of immune deficiency
- autoimmunity and autoimmune diseases (eg, Coombs positive hemolytic anemia, cryoglobulinemias, ITP)
- anemia of chronic disease
- transfusion complications, transplant rejection
- traumatic and mechanical injury (eg, mechanical injury to erythrocytes, splenic rupture)
- neoplastic disorders (eg, lymphoma, leukemia, multiple myeloma)
- metabolic and regulatory disorders, including acquired and congenital
- anemias and cytopenias (eg, iron deficiency anemia, hemoglobinopathies, hereditary spherocytosis)
- cythemia
- hemorrhagic and hemostatic disorders (eg, coagulopathies, DIC)
- bleeding secondary to platelet disorders (eg, von Willebrand)
- vascular and endothelial disorders (eg, effects and complications of splenectomy, hypersplenism, TTP, hemolytic uremic syndrome)
- systemic disorders affecting the hematopoietic and lymphoreticular system (eg, nutritional deficiencies, systemic lupus erythematosus)
- idiopathic disorders
Principles of therapeutics
- mechanisms of action, use, and adverse effects of drugs for treatment of disorders of the hematopoietic system
- blood and blood products
- treatment of anemia, drugs stimulating erythrocyte production (eg, erythropoietin)
- drugs stimulating leukocyte production (eg, G-CSF, GM-CSF)
- anticoagulants, thrombolytic drugs
- antiplatelet drugs
- antimicrobials (eg, antimalarials, anti-HIV)
- antineoplastic and immunosuppressive drugs
- drugs used to treat acquired disorders of immune responsiveness
- other therapeutic modalities (eg, splenectomy, chelating agents, radiation therapy for lymphomas, plasmapheresis)
Gender, ethnic, and behavioral considerations affecting disease treatment and prevention, including psychosocial, cultural, occupational, and environmental
- emotional and behavioral factors (eg, diet, depression and immune responses, “blood doping” among athletes)
- influence on person, family, and society (eg, childhood leukemia)
- occupational and other environmental risk factors (eg, heavy metals, hydrocarbons, lead)
- gender and ethnic factors (eg, herbal treatments with bone marrow depression)
source: usmle.org
Categorised as: Hematology 1