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Clostridium difficile MCQs

A 45 year old woman undergoes an uneventful laparoscopic cholecystectomy for which she receives one dose of cephalosporin. One week later, she returns to the emergency room with fever, nausea, and copious diarrhea and is subsequently diagnoed with peudomembranous colitis. With respect to this disease, which one of the following statements is correct?

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a. Surgical intervention is frequently required

b. After appropriate antibiotic therapy, the relapse rate is less than 5%

c. Tissue culture assay for C. difficile toxin B is neither sensitive nor specific; therefore, diagnosis should be based on clinical findings

d. If surgery is performed, a left hemicolectomy is usually adequate to treat pseudomembranous coliti

e. Indications for surgical treatment include intractable disease, failure of medical therapy, toxic megacolon, and colonic perforation

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The answer is e. (Brunicardi, p. 1100)

Indications for surgical treatment of C. difficile colitis are intractable disease, failure of medical therapy, toxic megacolon, and colonic perforation; surgical therapy consists of subtotal colectomy with end ileostomy.

The diagnosis can be made by either detection of the characteristic appearance of pseudomembranes on endoscopy or detectionof either toxin A or toxin B in the stool.

Treatment is metronidazole for first-line therapy and oral vancomycin as a second tier agent.

Recurrence appears in up to 20% of patients.

IMAGES OF POPULAR TEST PREP BOOKS

MCAT

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USMLE STEP 1

CLINICAL ROTATIONS

ABSITE
ABSITE KILLER Q&A

STUDY SCHEDULE FOR FUTURE   QUESTIONS

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12/29 USMLE  Clostridium difficile MCQs
12/30 ABSITE SMA syndrome MCQs
12/31 MCAT Verbal Passage 1 Question #2
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COLON
Colon anatomy MCQs
Colon physiology MCQs
Familial adenomatous polyposis MCQs
Colonoscopy MCQs
HNPCC (Lynch’s syndrome) MCQs
Colorectal cancer MCQs
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ESOPHAGUS
Esophagus anatomy MCQs
Esophagus physiology MCQs
Achalasia MCQs
Esophageal leiomyoma MCQs
Caustic esophageal injury MCQs
Barrett’s esophagus MCQs
Gastroesophageal reflux disease (GERD)
Zenker’s diverticulum
Hiatal Hernias
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Anastomotic leaks
Esophageal perforation
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THYROID
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Thyroid physiology MCQs
Hyperthyroidism MCQs
Hypothyroidism MCQs
Thyroid cancer MCQs
Thyroidectomy MCQs
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PARATHYROID
Parathyroid anatomy MCQs
Parathyroid physiology MCQs
Hyperparathyroidism MCQs
Hypoparathyroidism MCQs
Parathyroidectomy MCQs
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ARCHIVE MCQs
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MCAT VERBAL REASONING
MCAT Verbal Reasoning Passage 1 Question 1 .

SMALL INTESTINES
Carcinoid tumors MCQs .
Small bowel syndrome MCQs .
Ulcerative colitis vs Crohns disease MCQs .
Crohn’s Disease MCQs .
Meckel’s Diverticulum MCQs .
Small bowel obstruction MCQs .
Small bowel tumors MCQs .
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APPENDIX
Appendicitis MCQs .
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ONCOLOGY
Carcinoid tumors MCQs .
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Categorised as: Clostridium difficile


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