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Daily ABSITE MCQs

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ABSITE QUESTION OF THE DAY
Unique to this site is that every day we post new ABSITE questions.

SOURCE: SCHWARTZ

 

QUESTION: 10/28/12

Helicobacter pylori causes increased acid production in the stomach by

.

a. stimulation of parietal cells

b. inhibition of D cells

c. stimulation of cells of Cajal

d. Inhibition of G cells

.

.

.

.

.

– The answer is B.

 

MECHANISM OF ACTION REVIEW

 

 

– H. pylori inhibits antral D cells that secrete somatostatin

– There is an inhibitory effect that H. pylori exerts on antral D cells that secrete somatostatin, a potent inhibitor of antral G-cell gastrin production.

 

– Somatostatin secretion is reduced

– H. pylori infection is associated with decreased levels of somatostatin, decreased somatostatin mRNA production, and fewer somatostatin-producing D cells.

 

 

– Inhibition of antral-G cell gastrin production is reduced

 

– H. pylori also induces alkanization which also induces gastric secretion

– H. pylori induced local alkalinization of the antrum leads to increased gastrin secretion because antral acidification is the most potent antagonist to antral gastrin secretion.

 

– H. pylori also mediates increases in other local mediators and cytokines.

 

 

 

– H. pylori causes a disturbance in gastric acid secretion

– One of the mechanisms by which Helicobacter causes gastric injury may be through a disturbance in gastric acid secretion.

 

– The result of H.pylori effects is hypergastrinemia and acid hypersecretion.

 

 

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