Daily ABSITE MCQs
ABSITE QUESTION OF THE DAY
Unique to this site is that every day we post new ABSITE questions.
Helicobacter pylori causes increased acid production in the stomach by
a. stimulation of parietal cells
b. inhibition of D cells
c. stimulation of cells of Cajal
d. Inhibition of G cells
– The answer is B.
MECHANISM OF ACTION REVIEW
– H. pylori inhibits antral D cells that secrete somatostatin
– There is an inhibitory effect that H. pylori exerts on antral D cells that secrete somatostatin, a potent inhibitor of antral G-cell gastrin production.
– Somatostatin secretion is reduced
– H. pylori infection is associated with decreased levels of somatostatin, decreased somatostatin mRNA production, and fewer somatostatin-producing D cells.
– Inhibition of antral-G cell gastrin production is reduced
– H. pylori also induces alkanization which also induces gastric secretion
– H. pylori induced local alkalinization of the antrum leads to increased gastrin secretion because antral acidification is the most potent antagonist to antral gastrin secretion.
– H. pylori also mediates increases in other local mediators and cytokines.
– H. pylori causes a disturbance in gastric acid secretion
– One of the mechanisms by which Helicobacter causes gastric injury may be through a disturbance in gastric acid secretion.
– The result of H.pylori effects is hypergastrinemia and acid hypersecretion.
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