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ABSITE Question of the Day

ABSITE Question of the Day

COMPLICATIONS OF INFLAMMATORY BOWEL DISEASE

Which of the following is an extraintestinal manifestation of inflammatory bowel disease?

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a. hepatosteatosis

b. primary sclerosing cholangitis

c. pericholangitis

d. all of the above

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.

.

.

.

– The answer is D.

– The liver is a common site of extracolonic disease in inflammatory bowel diseases.

– Fatty infiltration of the liver is present in 40 to 50% of patients and cirrhosis is found in 2 to 5%.

– Fatty infiltration may be reversed by medical or surgical treatment of colonic disease, but cirrhosis is irreversible.

– Primary sclerosing cholangitis is a progressive disease characterized by intra- and extrahepatic bile duct strictures.

– 40 – 60% of patients with primary sclerosing cholangitis have ulcerative colitis.

– Colectomy will not reverse this disease, and the only effective therapy is liver transplantation.

– Pericholangitis also is associated with inflammatory bowel disease and may be diagnosed with a liver biopsy.

– Bile duct carcinoma is a rare complication of long-standing inflammatory bowel disease.

– Patients who develop bile duct carcinoma in the presence of inflammatory bowel disease are, on average, 20 years younger than other patients with bile duct carcinoma..

 

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