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USMLE STEP 1 REVIEW QUESTIONS: DESMOID TUMORS

USMLE STEP 1 REVIEW QUESTIONS: DESMOID TUMORS

QUESTION: What gene is associated with desmoid tumors of the chest wall?

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ANSWER: Adenomatous polyposis coli (APC)

– Desmoid tumors have recently been shown to possess alterations in the adenomatous polyposis coli / Beta-catenin pathway, and cyclin D1 dysregulation is thought to play a significant role in their pathogenesis.

– Associations with other diseases and conditions are well documented, especially those with similar alterations in the adenomatous polyposis coli pathway, such as familial adenomatous polyposis (Gardner’s syndrome).

 

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