First Aid for the USMLE Step 1 2010

Click on the link or image below to read student reviews or get this book.

First Aid for the USMLE Step 1 2010

USMLE Step 1 Books

The hard part about studying for Step 1  is deciding which books to use to study for each section of the USMLE. Below is an (almost) complete list of resources.

To help you decide, click on the links to any of the books to read student reviews.

COMPREHENSIVE

First Aid for the USMLE Step 1 2010 .
First Aid for the USMLE Step 1 2009 .
First Aid Q&A for the USMLE Step 1 .
First Aid Cases for the USMLE Step 1 .
Pathophysiology for the Boards and Wards .
medEssentials: High-Yield USMLE Step 1 Review (Kaplan Medessenitals for the USMLE Step 1
Kaplan Medical USMLE Examination Flashcards: The 200 “Most Likely Diagnosis” Questions You Will See on the Exam for Steps 2 & 3

Kaplan Medical USMLE Step 1 Qbook
Step-Up to USMLE Step 1
Step-Up to USMLE Step 1: A High-Yield, Systems-Based Review for the USMLE Step 1
Underground Clinical Vignettes Step 1 Bundle
Underground Clinical Vignettes Step 1: Pathophysiology II: GI, Neurology, Rheumatology, Endocrinology
Underground Clinical Vignettes Step 1: Pathophysiology I: Pulmonary, Ob/Gyn, ENT, Hem/Onc
Underground Clinical Vignettes Step 1: Pathophysiology III: CV, Dermatology, GU, Orthopedics, General Surgery, Peds
Underground Clinical Vignettes Step 1: Microbiology I: Virology, Immunology, Parasitology, Mycology
Underground Clinical Vignettes Step 1: Microbiology II: Bacteriology
Blueprints Q&A Step 1
Appleton & Lange Practice Tests for the USMLE Step 1
Appleton & Lange Review for the USMLE Step 1
Clinical Vignettes for the USMLE Step 1: PreTest Self-Assessment and Review

ANATOMY

Underground Clinical Vignettes Step 1: Anatomy
USMLE Road Map: Gross Anatomy
Rapid Review: Anatomy Reference Guide
Rapid Review Gross and Developmental Anatomy: With STUDENT CONSULT Online Access

BEHAVIORAL SCIENCES
High-Yield Behavioral Science by Fadem .
Rapid Review Behavioral Science: With STUDENT CONSULT Online Access
Underground Clinical Vignettes Step 1: Behavioral Science

BIOCHEMISTRY
Underground Clinical Vignettes Step 1: Biochemistry
Rapid Review Biochemistry: With STUDENT CONSULT Online Access

CELL BIOLOGY
Rapid Review Histology and Cell Biology: With STUDENT CONSULT Online Access

EMBRYOLOGY
High-Yield Embryology by Dudek .

EPIDEMIOLOGY AND BIOSTATISTICS
Appleton and Lange’s Review of Epidemiology and Biostatistics for the USMLE

HISTOLOGY
Rapid Review Histology and Cell Biology: With STUDENT CONSULT Online Access

LABORATORY MEDICINE
Rapid Review Laboratory Testing in Clinical Medicine: with STUDENT CONSULT Access

MICROBIOLOGY
Clinical Microbiology Made Ridiculously Simple .
Blackwell’s Underground Clinical Vignettes: Microbiology, Volume 2, Step 1
Rapid Review Microbiology and Immunology: With STUDENT CONSULT Online Access

NEUROLOGY
Rapid Review Neuroscience

PATHOLOGY
USMLE Road Map Pathology
Rapid Review Pathology: With STUDENT CONSULT Online Access

PHARMACOLOGY
Kaplan Medical USMLE Pharmacology and Treatment Flashcards: The 200 Questions You’re Most Likely to See on the Exam For Steps 1, 2 & 3
Underground Clinical Vignettes Step 1: Pharmacology
USMLE Road Map: Pharmacology
Rapid Review Pharmacology: With STUDENT CONSULT Online Access

PHYSIOLOGY
BRS Physiology by Costanzo .
USMLE Road Map: Physiology .
Rapid Review Physiology: With STUDENT CONSULT Online Access .

PICTURES! YOU CAN CLICK ON THEM IF YOU WANT TO READ STUDENT REVIEWS.

As more resources become available, I will add them here.

USMLE Step 1 Books

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Quantitative methods for USMLE Step 1

Quantitative methods

• fundamental concepts of measurement
  • scales of measurement
  • distribution, central tendency, variability, probability
  • disease prevalence and incidence
  • disease outcomes (eg, fatality rates)
  • associations (eg, correlation and covariance)
  • health impact (eg, risk differences and ratios)
  • sensitivity, specificity, predictive values
• fundamental concepts of study design
  • types of experimental studies (eg, clinical trials, community intervention trials)
  • types of observational studies (eg, cohort, case-control, cross-sectional, case series, community surveys)
  • sampling and sample size
  • subject selection and exposure allocation (eg, randomization, stratification, self-selection, systematic assignment)
  • outcome assessment
  • internal and external validity
• fundamental concepts of hypothesis testing and statistical inference
  • confidence intervals
  • statistical significance and Type I error
  • statistical power and Type II error

Quantitative methods for USMLE Step 1

Immune responses for USMLE Step 1

Immune responses

• production and function of granulocytes, natural killer cells, and macrophages
• production and function of T lymphocytes, T-lymphocyte receptors
• production and function of B lymphocytes and plasma cells; immunoglobulin and antibodies: structure and biologic properties
• antigenicity and immunogenicity; antigen presentation; cell activation and regulation; tolerance and clonal deletion
• immunologic mediators: chemistry, function, molecular biology, classic and alternative complement pathways, cytokines, chemokines
• immunogenetics; MHC structure and function, class I, II molecules; erythrocyte antigens
• immunizations: vaccines, protective immunity
• alterations in immunologic function
  • T- or B-lymphocyte deficiencies (eg, DiGeorge syndrome)
  • deficiencies of phagocytic cells
  • combined immunodeficiency disease
  • HIV infection/AIDS and other acquired disorders of immune responsiveness
  • drug-induced alterations in immune responses, immunopharmacology
• immunologically mediated disorders
  • hypersensitivity (types I–IV)
  • transplant and transplant rejection
  • autoimmune disorders
  • risks of transplantation, transfusion (eg, graft-versus-host disease)
  • isoimmunization, hemolytic disease of the newborn
  • immunopathogenesis
• immunologic principles underlying diagnostic laboratory tests (eg, ELISA, complement fixation, RIA, agglutination)
• innate immunity

Biology of tissue response to disease

• inflammation, including cells and mediators
  • acute inflammation and mediator systems
  • vascular response to injury, including mediators
  • inflammatory cell recruitment, including adherence and cell migration, and phagocytosis
  • bactericidal mechanisms and tissue injury
  • clinical manifestations (eg, pain, fever, leukocytosis, leukemoid reaction, and chills)
  • chronic inflammation
• reparative processes
  • wound healing, hemostasis, and repair: thrombosis, granulation tissue, angiogenesis, fibrosis, scar/keloid formation
  • regenerative processes
• neoplasia
  • tumor immunology

Immune responses for USMLE Step 1

Microbial biology and infection for USMLE Step 1

Microbial biology and infection

• microbial classification and its basis
• bacteria and bacterial diseases
  • structure and composition
  • metabolism, physiology, and regulation
  • genetics
  • nature and mechanisms of action of virulence factors
  • pathophysiology of infection
  • epidemiology and ecology
  • principles of cultivation, assay, and laboratory diagnosis
• viruses and viral diseases
  • physical and chemical properties
  • replication
  • genetics
  • principles of cultivation, assay, and laboratory diagnosis
  • molecular basis of pathogenesis
  • pathophysiology of infection
  • latent and persistent infections
  • epidemiology
  • oncogenic viruses
• fungi and fungal infections
  • structure, physiology, cultivation, and laboratory diagnosis
  • pathogenesis and epidemiology
• parasites and parasitic diseases
  • structure, physiology, and laboratory diagnosis
  • pathogenesis and epidemiology
• principles of sterilization and pure culture technique

Microbial biology and infection for USMLE Step 1

Pharmacodynamic and pharmacokinetic processes for USMLE Step 1

Pharmacodynamic and pharmacokinetic processes

• general principles
  • pharmacokinetics: absorption, distribution, metabolism, excretion, dosage intervals
  • mechanisms of drug action, structure-activity relationships
  • concentration- and dose-effect relationships (eg, efficacy, potency), types of agonists and antagonists and their actions
  • individual factors altering pharmacokinetics and pharmacodynamics (eg, age, gender, disease, tolerance, compliance, body weight, metabolic proficiency, pharmacogenetics)
  • drug side effects, overdosage, toxicology
  • drug interactions
  • regulatory issues (eg, drug development, approval, scheduling)
• general properties of autacoids, including peptides and analogs, biogenic amines, prostanoids and their inhibitors, and smooth muscle/endothelial autacoids
• general principles of autonomic pharmacology
• general properties of antimicrobials, including mechanisms of action and resistance
• general properties of antineoplastic agents and immunosuppressants, including drug effects on rapidly dividing mammalian cells

Pharmacodynamic and pharmacokinetic processes for USMLE Step 1

Gastrointestinal topics for USMLE Step 1

Gastrointestinal System

Normal processes

• embryonic development, fetal maturation, and perinatal changes
• organ structure and function, including alimentary canal, liver and biliary system, salivary glands and exocrine pancreas, motility, and digestion and absorption
• cell/tissue structure and function
  • endocrine and neural regulatory functions, including GI hormones
  • salivary, gastrointestinal, pancreatic, hepatic secretory products, including enzymes, proteins, bile salts, and processes
  • synthetic and metabolic functions of hepatocytes
• repair, regeneration, and changes associated with stage of life
• gastrointestinal defense mechanisms and normal flora

Abnormal processes

• infectious, inflammatory, and immunologic disorders
  • infectious disorders (eg, peritonitis, hepatitis, gingivostomatitis, peptic ulcer, gastritis, esophagitis, traveler’s diarrhea, food poisoning)
  • inflammatory disorders (eg, cholecystitis, pancreatitis)
  • immunologic disorders (eg, Crohn disease, ulcerative colitis)
• traumatic and mechanical disorders
  • malocclusion
  • hiatus hernia
  • obstruction (eg, volvulus, intussusception, esophageal atresia, annular pancreas, postsurgical obstruction)
  • perforation of hollow viscus and blunt trauma
  • inguinal, femoral, and abdominal wall hernias
  • esophageal and intestinal diverticula (eg, Meckel diverticulum)
• neoplastic disorders, including benign and malignant
• metabolic and regulatory disorders (eg, motility disorders, malabsorption, hepatic failure, cholelithiasis)
• vascular disorders (eg, portal hypertension, esophageal varices, hemorrhoids, anal fissure, ischemia, angiodysplasia, thromboses, vasculitis)
• systemic disorders affecting the gastrointestinal system

Principles of therapeutics

• mechanisms of action, use, and adverse effects of drugs for treatment of disorders of the gastrointestinal system
  • treatment and prophylaxis of peptic ulcer disease and gastroesophageal reflux (eg, antacids, antisecretory drugs, motility drugs, mucosal protective agents, antibiotics)
  • drugs to alter gastrointestinal motility (eg, cathartics, antidiarrheal drugs, antiemetic drugs, prokinetic drugs)
  • fluid replacement (eg, oral rehydration)
  • pancreatic replacement therapy and treatment of pancreatitis
  • drugs for treatment of hepatic failure (eg, lactulose) and biliary disease (eg, drugs to dissolve gallstones)
  • anti-inflammatory, immunosuppressive, antineoplastic, and antimicrobial drugs
• other therapeutic modalities (eg, surgical procedures, stents, feeding tubes)

Gender, ethnic, and behavioral considerations affecting disease treatment and prevention, including psychosocial, cultural, occupational, and environmental

• emotional and behavioral factors (eg, peptic ulcer, encopresis, Monday morning stomach)
• influence on person, family, and society (eg, inflammatory bowel disease, irritable bowel disease, pancreatitis and alcohol, chronic laxative abuse)
• occupational and other environmental risk factors
• gender and ethnic factors (eg, diets)

Multisystem processes

• nutrition
  • generation, expenditure, and storage of energy at the whole-body level
  • assessment of nutritional status across the life span, including calories, protein, essential nutrients, hypoalimentation
  • functions of nutrients, including essential, trans-fatty acids, cholesterol
  • protein-calorie malnutrition
  • vitamin deficiencies and/or toxicities
  • mineral deficiencies and toxicities
  • eating disorders (eg, obesity, anorexia, bulimia, alternative diets, and nutritional supplements)
• temperature regulation
• adaptation to environmental extremes, including occupational exposures
  • physical and associated disorders (eg, temperature, radiation, burns, decreased atmospheric pressure, high-altitude sickness, increased water pressure)
  • chemical (eg, gases, vapors, smoke inhalation, agricultural hazards, volatile organic solvents, heavy metals, principles of poisoning and therapy)
• fluid, electrolyte, and acid-base balance and disorders (eg, dehydration, acidosis, alkalosis)

Gastrointestinal topics for USMLE Step 1

Psychiatry topics for USMLE Step 1

Gender, ethnic, and behavioral considerations affecting disease treatment and prevention, including psychosocial, cultural, occupational, and environmental

• progression through the life cycle, including birth through senescence
  • cognitive, language, motor skills, and social and interpersonal development
  • sexual development (eg, puberty, menopause)
  • influence of developmental stage on physician-patient interview
• psychologic and social factors influencing patient behavior
  • personality traits or coping style, including coping mechanisms
  • psychodynamic and behavioral factors, related past experience
  • family and cultural factors, including socioeconomic status, ethnicity, and gender
  • adaptive and maladaptive behavioral responses to stress and illness (eg, drug-seeking behavior, sleep deprivation)
  • interactions between the patient and the physician or the health care system (eg, transference)
  • patient adherence, including general and adolescent
• patient interviewing, consultation, and interactions with the family
  • establishing and maintaining rapport
  • data gathering
  • approaches to patient education
  • enticing patients to make lifestyle changes
  • communicating bad news
  • “difficult” interviews (eg, anxious or angry patients)
  • multicultural ethnic characteristics
• medical ethics, jurisprudence, and professional behavior
  • consent and informed consent to treatment
  • physician-patient relationships (eg, ethical conduct, confidentiality)
  • death and dying
  • birth-related issues
  • issues related to patient participation in research
  • interactions with other health professionals (eg, referral)
  • sexuality and the profession; other “boundary” issues
  • ethics of managed care
  • organization and cost of health care delivery

Psychiatry topics for USMLE Step 1

Genetics topics for USMLE Step 1

Human development and genetics

• embryogenesis: programmed gene expression, tissue differentiation and morphogenesis, homeotic genes, and developmental regulation of gene expression
• congenital abnormalities: principles, patterns of anomalies, dysmorphogenesis
• principles of pedigree analysis, including inheritance patterns, occurrence and recurrence risk determination
• population genetics: Hardy-Weinberg law, founder effects, mutation-selection equilibrium
• genetic mechanisms: chromosomal abnormalities, mendelian inheritance, multifactorial diseases
• clinical genetics, including genetic testing, prenatal diagnosis, newborn screening, genetic counseling/ethics, gene therapy

Human development and genetics for USMLE Step 1

Cell biology topics for USMLE Step 1

Biology of cells

• structure and function of cell components (eg, endoplasmic reticulum, Golgi complex, mitochondria, lysosome, peroxidase, endosome, centriole, microtubule, ribosome, polysome, plasma membrane, cytosol, cilia, nucleus, cytoskeleton,)
• signal transduction (including basic principles, receptors and channels, second messengers, signal trasnduction pathways)
• cell-cell and cell-matrix adhesion
• cell motility
• intracellular sorting (eg, trafficking, endocytosis)
• cellular homeostasis (eg, turnover, pH maintenance, proteasome, ions, soluble proteins)
• cell cycle (eg, mitosis, meiosis, structure of spindle apparatus, cell cycle regulation)
• structure and function of basic tissue components (including epithelial cells, connective tissue cells, muscle cells, nerve cells, and extracellular matrix)
• adaptive cell response to injury
• intracellular accumulations (eg, pigments, fats, proteins, carbohydrates, minerals, inclusions, vacuoles)
• mechanisms of injury and necrosis
• apoptosis

Biology of cells for USMLE Step 1

source: http://usmle.org/Examinations/step1/content/principles.html